Older sperm and schizoprenia

Mutation Research-Reviews in Mutation Research. The condition, which can present on a spectrum from mild to severe, is usually recognized in the first two years of life and is consistently associated with APA. Copy Number, Schizophrenia, and Autism: Competition from other men stimulates production of higher quality semen, increasing the chances of procreation. Previous studies have shown that men tend to prefer the kind of "sperm competition" images used in the study. Infection is another risk factor discussed in the review and one that I have dealt with in a previous post. Longer telomere length is frequently mentioned as a potential benefit of later paternal age, as it is a predictor of longevity.
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Ontario families sue sperm bank, distributor over ‘schizophrenic’ donor - The Globe and Mail

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Sperm has evolved to stay fresh

They concluded that relative to children born to to years-old fathers, those with fathers aged 30 to 39 were 1. Now that we know the effects are driven by differences across half-siblings, we can start asking what else — beyond paternal age — might be driving the difference. To compound matters, DNA-repair enzymes become less efficient as a man ages and more frequently fail to fix a mutant sperm. Competition from other men stimulates production of higher quality semen, increasing the chances of procreation.
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For reduced risk of children with schizophrenia, men should have children while they are younger, rather than older. After poring over the medical records of more than 87, people born between and — of whom had been diagnosed with schizophrenia or closely related psychoses — Malaspina reached a startling conclusion. The volunteers had previously abstained from sexual activity for two to six days. This suggests to me that any male over 25 may produce a child with this mental disorder. Consequently, the disease cannot be but uncommon compared to infectious disease and respiratory problems.
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But no matter how they swung the models, those new mutations that accumulate in sperm could only explain between 10 and 20 percent of that increased risk, said lead study author Jacob Gratten, a neurogeneticist at the University of Queensland, who reported the findings in Nature Genetics. And clearly, if this is the case, then the finding that gestational diabetes is a risk factor for autism is exactly what the theory would lead you to expect. Austim is defined by persistent deficits in social communication and social interaction; restricted, repetitive patterns of behavior, interests, or activities and significant impairments in social, academic and occupational functioning. Bipolar disorder, also known as manic-depressive illness is typified by cycles of mania and depression, including shifts in mood, energy, activity levels, and the ability to carry out daily tasks. Indeed, as I point out in The Imprinted Brain, this factor alone could explain the exponential rise in mild ASD in modern, affluent societies, where maternal nutrition is demonstrably better than it has ever been in the past. The men viewed explicit pictures that featured either two men and a woman or three women and collected a sperm sample.
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